How does CBD affect the Endocannabinoid System?

by BM Innovations on October 09, 2023

The status of Cannabis has taken 180 degrees turn worldwide. The Endocannabinoid system is closely related to Cannabinoids; therefore, let’s first get to know Cannabinoids.  

What are Cannabinoids? 

The cannabis plant consists of various substances that impart Cannabis its beneficial effects. These substances are Cannabinoids, and above 150 Cannabinoids have come up so far. A plant goes through different conditions when exposed to sunlight and a varying external environment. These factors induce change in the chemical structure of plant components, and that's how they evolve into different Cannabinoids like CBD, THC, CBG, CBN, etc. Cannabinoids are responsible for the effects that appear in the body after Cannabis consumption. Nonetheless, do you wonder how these Cannabinoids give rise to such changes? It's through the Endocannabinoid system.  

What is the Endocannabinoid System? 

We have been hearing a lot about the jaw-dropping effects of CBD lately. There is a complete system of receptors and neurotransmitters in the body that tackle the effects of pure CBD and other Cannabinoids; this is the Endocannabinoid system. In 1990, scientists experimented on rat models and found that Cannabinoids bound to a specific receptor to elicit effects.  

Role of Endocannabinoid System: 

That being said, Cannabis won't cause any significant effect on the body if the Endocannabinoid system is not present. The Endocannabinoid system deals with the cannabinoids through its three main parts that are: 

  • Endocannabinoid or neurotransmitters 
  • Receptors to which they bind 
  • Enzymes that speed up the reaction 

CBD elicits specific changes in mood, pain, inflammation and other physiological and psychological conditions. It does so by altering, maintaining, and regulating the homeostasis in the body. It is an undeniable fact that CBD has the potential to replace conventional medicines for various drugs by virtue of the Endocannabinoid system.  

What are Endocannabinoids? 

Endocannabinoids are responsible for bringing about the actions of Cannabis. They act as neurotransmitters inside the body, and they are similar to the Cannabinoids from Cannabis. Endocannabinoids have controlled production according to the body's need, and it helps smooth the functioning of pure natural CBD.  

What are Endocannabinoid Receptors? 

You will often come across CB1 and CB2 while studying the primary body receptors associated with Cannabis. They are Endocannabinoid receptors that facilitate the transmission of Cannabinoids in the body. They are G-protein coupled receptors primarily found in the brain and rarely in peripheral nerves, spleen, and eyes. It will surprise you that CBD has antagonizing activity at both CB1 and CB2 receptors. It acts differently on each receptor according to the situation.  

Relationship of CBD with Endocannabinoid system: 

Pure CBD oil interacts with the Endocannabinoid system in many ways. CBD and THC have different behaviours when we talk about how they interact with Endocannabinoid receptors. CBD won't bind directly to these receptors as THC does. It indirectly works as an antagonizer and reduces the production of certain substances that carry out a few mechanisms to make you feel good! 


If you are looking for a CBD boutique to get your CBD product that will maximally affect ECS, you must be careful. There have been a lot of scams in the CBD market lately; therefore, checking on a genuine pure hemp shop for pure brand CBD oil will help you get the desired results. You may take help from customer reviews and third-party lab tests in this regard.